Tuesday, December 26, 2017

Mjolnir: making the famous hammer of the gods

I made a replica of Mjolnir according to the classic descriptions (as opposed to the well known comic book version).  Unfortunately, Tony and I were both concerned that it might be too brittle for casual use during a party, so he used an alternative, but I was generally happy with the look and it has a great heft.  I'm definitely going to use plaster like this again in the future.


Mjolnir, crafted in the classic Norse style

Saturday, December 23, 2017

Check out this quick-connect system for printing cells

In order to print cells, I need to be able to load up a syringe, then connect that syringe to a printer as quickly and simply as possible.  My first attempt has been to make a bracket that holds the syringe and a connector that snaps together with a mate to instantly link the syringe plunger to a motor.  Today I set it all up for the first time and ran it off a laptop connected to the printer over a live USB connection.  It's a little clumsy with one hand, but for a first approach, it looks more than serviceable.  I'm eager to mount this extruder on to the x/y gantry and then try it out with live cells in it.


Monday, December 18, 2017

Loki, Thor, and Heimdall at a gathering of the gods

Last weekend, we went to a truly amazing party.  In celebration of the solstice, everyone was asked to come in the guise of one of the ancient deities.  Upon arriving, we were each given three coins labeled with the powers conferred by our characters, and told that we could not use the powers, but were able to trade them and use the ones we received.  We were also each given personalized win conditions.  I attended as Loki, the god of mischief.  Tony attended as the mighty Thor.  Jack came as Heimdall, the watchman.  And we had a blast.  The Egyptian gods, Greek gods, and Aztec gods were present, but the Norse gods clearly owned the night.

At the party, I arrived in the guise of Sif, Thor's wife and goddess of the Earth.  Heimdall was given instructions to reveal me, so I spent the beginning of the party trying to evade discovery.  Eventually, after several thwarted attempts to uncover me, Odin and the rest of the Norse gods used some in-game spell to force me to appear.  This attracted everyone's attention to follow the drama, which afforded me the opportunity to gift one of my coins -- labeled "Chaos" -- to a friend, who immediately used it to force everyone within ten feet to randomly exchange the coins they'd worked so hard to trade and acquired.  Tony, Jack, and I all were shocked at how instantly the room was thrown into genuine pandemonium.  

Over the course of the evening, I changed wigs and masks several times, teased the other gods and stirred up fun.  I can honestly say I've never received so much positive attention at a party.  Loki is a hilariously fun character to play.  Tony made a super-fun Thor too.  In fact, all the folks who'd come as Norse characters -- Odin, Freyr, Sunna, Mani -- seemed to be the most lively attendees.  The entire Norse lineup owned the night.

From left to right: Heimdall, Freyr, Thor, Sjöfn, Odin, Sunna, Mani, Loki

Heimdall and "Sif"

Thor arm wrestles Maat, Egyptian god of Justice

Heimdall and Loki

Thor & Heimdall


Thor addresses his fellow gods

Sunday, August 27, 2017

Building a 3D Printer, Burying Your Father-in-law, and Other Ways to Spend the Summer

This summer has been pretty nuts.

Work

In June, our department encouraged participants to pitch an idea in 5 minutes that could be funded with $3,000.  I suggested that we buy a 3D printer and won.  This meant that I got to buy a 3D printer for our department and establish guidelines for its use.  It also kicked off my boss' long-held interest in 3D bioprinting.  Regular 3D printing binds plastic into complex shapes in order to make 3D objects out of plastic.  Bioprinting is a very experimental process in which cells are arranged in 3D instead of bits of plastic in order to create 3D objects made of of cells.  So we bought a kit and now I'm building a 3D bioprinter in addition to the regular 3D printer that I'm having a lot of fun with.

On the right is our department's first printer.  On the left is our lab's new experimental bioprinter.

Recreation

I've been working (so... so... slooowwly) on my underwater robot.  It's been one 'learning experience' after another, but that's how these things go.  I also got a new computer and a couple of games.  I'm playing Deus Ex: Human Revolution, which is an RPG about a guy who works for a synthetic biology firm that engineers replacement organs and parts.  I find this funny, because it's like what I do in real life (if I were a former cop injured by terrorists and saved on an operating table by millions of dollars of cybernetics).

It's a robot.  Look closely, I swear it is!

Jack

Jack landed a job at SpaceX working as a production optimization engineer.  The production team that builds the rockets constantly needs specialized new tools or modifications to existing tools to make their work easier: a custom parts rack, a table with holes for connecting wires, a clip to hold something in place during assembly, etc.  This isn't a team of people, it's just a single position to help out the production folks.  I met some of Jack's coworkers last Friday for the first time, and when they were telling me what their jobs were one of them remarked that Jack's job sounded cool, which confirmed for me that it wasn't just me who thought that it sounded like a lot of fun.  It's long hours, but he seems to be digging it.  

Julie

First off, I'm going to start referring to Julie as "Tony" on this blog from now on because it's what I've called him for a year now.  I'll also call him 'him'.  Or sometimes I'll call her Julie because I don't think about it too much and I suggest that you don't either.

Tony has been having a stressful summer at work, where he has felt that human resource limitations have been hindering his ability to do his job effectively.  He's been writing fiction with a partner over email as a hobby for months and months, and doing so has brought several things into focus:

1) He really enjoys writing, particularly fiction.

2) He's good at it.

The second is a subjective point, but I'm a critical reader, and I believe that if I didn't know Tony I would gladly pay to read the stories he's shared with me.  You can judge for yourself (www.ialbatross.com). I know that he's dreamed of being a professional writer his whole life, but like me he is a practical type who thinks that creative careers are generally the pipe dreams of people lacking technical skill and a sober understanding of the challenges of getting paid to make art.  But I'm also aware that someone actually does have to get paid to write the novels, technical manuals, online humor, screenplays, and comic books we all enjoy, and if Tony is better than most of them then why the fuck shouldn't he compete for their jobs?  So I told him to go for it, and after lots of consideration he's agreed to begin pursuing freelance writing with the plan to leave his current job at the end of the year.  I won't be surprised if he has to find part-time work to make up the difference.  It probably won't be fast, and it might not work out at all.  But it also might, which would be awesome, and I think it's worth a solid shot.

Julie's Dad

Oh, he's dead.  

Unfortunately, Julie's father passed away at the age of 71.  I spent the last week in Illinois with Tony and his family as they organized arrangements and processed the loss of the family patriarch.  I can relate.  I lost my dad similarly in 2012.  The best thing you can have when this comes is a proud absence of regrets.  I knew and loved my Dad.  But Tony had gone through several years of estrangement with his father.  For several years, Tony's dad wasn't talking to any of their children.  But fortunately,  relationships had mended over the last several years.  Tony's grandfather and great-grandfather both passed away while not on speaking terms with their sons.  But in a toast to their father, Tony congratulated his brother that they'd broken 'the McGinn curse'.  It's no small achievement and it's no small solace in times of loss.  

I'm deeply grateful to the way that Vincent Paul McGinn welcomed me into his family.  I had doubts.  He was a devoutly old-school, conservative Catholic, and I was a godless secular Jew with unimpressive earnings and no doctorate or military service, his premier and only marks of official worth.  But ultimately, he expressed enthusiasm about making me a part of his family.  As we mourned, his widow, his sister, and all of his family made clear that I was a part of their family as though I were a blood relative.  It meant a lot.

Tony's Dad, circa 2002, at his 25th wedding anniversary.


My Grandmother

My mother, stepfather, and grandmother are currently at an antiques fair in Toronto, which is incredible because my grandmother broke her femor -- her fucking femor! -- in the end of March.  It's been almost five months exactly and she's walking around a convention.  I think she may have more in common with the cyberneticly augmented protagonist of Deus Ex than I do.  From my professional opinion working in regenerative medicine, I have no idea what the doctors did to my grandmother and I'm super glad they were able to repair her femur. 

Do you know what the femur is?  It's the upper leg.
Go check the link.  She broke it 5 months ago.  This is crazy.

My Computer

Remember how I mentioned I got a new computer? 

Oh, it's dead.

Well, not completely.  But it is completely inoperable at the moment.  It won't start up ever since I let Window's install an update.  I think I can fix it, though.  It appears that the update overwrote the partition table.  This means that during the update, Windows saw the file my computer reads at startup that tells it where to find all my files and said, 'Hold my beer'.  I am currently backing up the hard drive before I start trying to replace the partition table, which is why I'm blogging on my old laptop.  We'll see how it goes.

Dolly, the house guest

A friend in need of some assistance is crashing with us for a few months.  She's been a great house guest, and both Tony and I appreciate the help around the house, particularly in walking and cleaning up after Carlisle.  

This seems like enough for now.  Oh!  And look!  I got through the whole thing without talking about government and politics.  Nice!

Saturday, May 6, 2017

An Apparently Controversial Opinion About Cancer

Tomorrow is my 31st birthday, and I'm blessed with incredible health.  Which makes this a fitting time to make a statement that I feel needs to be said about my mortality.  I believe that it is most likely that when I die, it will be due to cancer.  And furthermore, I don't consider this a bad thing.

I went to a doctor for a general checkup last week, and asked to get my genome screened or sequenced in order to assess what hereditary diseases I'm at elevated risk for.  The doctor told me I was about five years early and that it wasn't an affordable or covered service yet, so I guess I'll just have to wait.  When I mentioned that I was fairly confident I'd die of cancer, she was taken aback.  "Why would you say that?" she asked.  Her tone was respectfully professional but without an effort to hide her disapproval that I would prognosticate my own cause of death.  Did she think I was being disrespectful to people with cancer?  Did she think I was being offensive in a general social sense by appearing to mock death?  I'm not entirely sure, but my Mom once gave me a similar reaction when I said the same thing a few years ago, and I recall Julie afterwards chastising me for what she thought was a tasteless thing to say to my mother.  I could imagine that part of the taboo might be that I look like a smug, over-confident prick by announcing that I believe I know what is considered one of life's great unknowables.

I don't understand why my relationship with my mortality reflects badly on me, but I know that it does and I know that not knowing why it does reflects badly on me as well.  If anyone wants to respectfully explain it, I'll listen and I'll probably act on your advice.  But for the record, this isn't a glib, thoughtless statement.

In the US in 2010, roughly 6 million of the 24 million people who died lost their lives to cancer.  Which means that just by sheer chance, I have roughly a 1 in 4 chance of dying of cancer, if I were to have expired in 2010.  So would you.

Additionally, my father died of cancer several years ago.  His sister has fought cancer successfully.  Their mother died of cancer when I was young.  So after he died, in the process of reflecting, it occurred to me: I'm a machine built on the same production line as those people.  And apparently that's a defect that happens to have been seen in that production line.

This by no means rules out the possibility of other deaths.  But consider the next likely causes.


Right alongside cancer is heart disease.  So if I didn't think further, I could make a similar prediction about the likelihood that when I go, it will be due to heart failure.  But diseases aren't random.  My family tree happens to be thin in suffers of heart disease.  Furthermore, risk of heart disease -- like cancer -- is the result of both genetics and lifestyle.  Consider this figure from the American Health Economy:


Heart disease is so prevalent because many people who lived through the last few decades ate poorly, didn't exercise, and smoked.  I've fallen out of the habit of flossing, but I take pretty good care of my body.  At the same time, my career exposes me to more chemicals and radiation sources than most people.  So we start with 25% and then bump it up for the greater likelihood relative to the next likely cause.  We can repeat this process with Lower Respiratory Diseases, just because I don't happen to work in mining or construction and my family has had good fortune with lung health.  Stroke and Alzheimer's are pretty much unchanged.  They're notoriously unpredictable, so I'm at as much a chance as anyone.  For unintentional injury I'm slightly reduced in probability as well.  I'm active, but I wear a helmet and generally exercise caution.  Most importantly, I have prompt access to medical care, which is the biggest factor in predicting mortality of a car crash or a fall.

And then we get to Diabetes.  Which introduces an important new wrinkle.  Now, I'm not going to die of Diabetes, because the genetic version usually manifests in childhood and I don't consume enough sugar to get the dietary version.  But more importantly, that is a disease we're on our way to licking.  I'm not sure we'll ever cure it completely, but like HIV, diabetes is a disease we can treat well enough to let someone live out a natural lifespan.  Justice of the Supreme Court Sonya Sotomayor was told she would probably not make it to 40 when she was initially diagnosed with diabetes at seven.  She is now 58, and is expected to rule on the bench for years to come.  Based on long term projections, even insulin shots will likely become obsolete in my lifetime, as procedures to replace cells like those missing in diabetics appear entirely achievable.

Although not all the causes of death listed above will see as much progress as diabetes, it reminds us that we must consider the direction of medicine in order to predict a similar chart for the middle of our new century.  All of these will likely see some improvement.  It's possible some will see a spike due to a modern health risk we aren't aware of right now.  Ultimately, though, as I look at the state of medical research in 2017 and what we know about etiology of disease, I think neurological degeneration, cancer, and heart disease are things that we delay, but may not stave off forever.  Once people don't die of infection or war, these are the things that get you if you survive everything else.  Of these three, my closest pursuer is likely cancer.  Nothing is indestructible, and our bodies like all things will eventually wear out.  But in predicting that I will die of cancer, I am predicting that I will die of it well after 80, perhaps after dealing with it for several active decades.

I consider myself at reduced risk for most of the common causes of death.  I consider myself at elevated risk for one of the leading causes of death.  And I envision a future in which the disease I am most susceptible to is one we can manage very effectively.  So when I say that I believe I am most likely going to die of cancer, it is because I plan my life with the expectation that I'm going to live it very fucking well.  This is how I find comfort with my mortality.  This makes me feel more prepared and in control in the face of something I know I am ultimately powerless against.  One day I will pass away from this Earth.  Hopefully, if I am successful in my endeavors, I will do so contended, proud, and utterly stuffed from the feast of life.  And when this day comes, I think the specific cause listed on the medical report will, as a matter of trivia, be cancer.

And I'm fine with that.